Endocrine Abstracts

Objective: To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.Methods and Results: A total of 8971 participants aged 40 years and older from Baoshan district, Shanghai were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30...

Hypogonadism is prevalent with opiate-like drug use and might be a factor in cognitive abnormalities. With the increasing substance use (SU) worldwide, it is critical to recognize its impact on cognition, which may decrease adherence to treatment and alter quality of life. We hypothesized that men with SU, by virtue of hypogonadism secondary to HIV and/or drug use, may demonstrate impaired cognitive function.We recruited men aged 18–50 from a low-in...

GnRH is released from the hypothalamus in a pulsatile manner and binds to specific receptors (GnRHR) in the anterior pituitary gland to stimulate follicle-stimulating hormone (FSH) and luteinizing hormone (LH) subunit gene expression and subsequent FSHβ and LHsecretion. The FSH and LH subunits are preferentially stimulated by pulsatile GnRH at low and high pulse frequencies, respectively. The transcription factors, cAMP response element binding protein (CREB) and inducibl...

SOM230 is one of the long-acting somatostatin analogues, which has been developed for the treatment of neuroendocrine tumours. Recently we found that SOM230 inhibits the proliferation of human umbilical vein endothelial cells (HUVECs). The aim of this study is to further investigate its antiproliferative effect using adult human aortic endothelial cells (HAECs) and human dermal microvessel endothelial cells (HDMECs). The expression of SSTRs and the potential mechanism were obs...

The adrenocorticotrophin hormone (ACTH) receptor, also known as the melanocortin-2-receptor (MC2R), is a key mediator of cortisol synthesis in the adrenal gland. Over 40 loss-of-function MC2R mutations have been described to give rise to familial glucocorticoid deficiency type-1 (FGD1). In contrast, to date only one naturally occurring gain-of-function mutation, F278C, has been identified in a patient with ACTH-independent Cushing’s syndrome. Previous work has demonstrate...

Objectives: Overweight and obesity currently burden our public health, and especially with the aging process in the world, the incidence of obesity is significantly higher in women than that in men partly. Recent studies reported that hypothalamic kisspeptin neurons, with obvious changes of number and structure in female during life, play a crucial role in the regulation of central energy homeostasis. But the precise mechanism remains an enigma.Methods: ...

Background: GEP-NETS and PPGLs in pediatric patients are rare; however, recognition of these diseases has increased recently. 10–20% of pediatric patients with GEP-NETs and up to 47% of pediatric patients with PPGLs present with metastatic disease at diagnosis. The disease is often unresectable with poor prognosis, and very few non-surgical therapies are approved for these patients. Due to paucity of data surrounding treatments for pediatric patients with advanced GEP-NET...

Obesity, as a chronic nutritional disorder, is a high-risk factor for type 2 diabetes, fatty liver and other metabolic diseases. Multiple lncRNAs have been confirmed concerning adipocyte differentiation and thus affect obesity, such as ADINR, Paral1, etc. Previously, we identified a lncRNA named ENST0000052114 (abbreviated to lncRNA52114), highly expressed in human mature adipocytes by differential lncRNA expression profile. Here, we explored the role and mechanism of lncRNA52...

Introduction: Adipocyte fatty acid binding protein (A-FABP) is a fatty acid chaperone that facilitates the efflux of free fatty acid from cytoplasm into circulation. Previous studies show that A-FABP knockout (KO) mice are more susceptible to diet-induced obesity comparing to wild type (WT) littermates. Here we investigate the underlying mechanism of A-FABP in the regulation of diet-induced obesity.Methods: A-FABP KO mice and their WT littermates were fe...

Introduction: We have previously demonstrated that APPL1 maintains glucose homeostasis by promoting both actions and secretion of insulin. Although APPL2 is a close homolog of APPL1, the physiological function of APPL2 is vaguely characterized. Thus, we generated a knockout (KO) mouse model in which APPL2 is deleted in pancreatic β-cells and hypothalamus (which is called APPL2 KO mice) to investigate its role in glucose and energy metabolism.Methods...